Gliclazide is a hypoglycemic agent used widely as monotherapy. It stimulates insulin secretion from functional pancreatic beta-cells and increases the sensitivity of the beta-cells to a glucose stimulus. The presence of a number of amino groups allows chitosan to react chemically with anionic systems, which results in alteration of physicochemical characteristics of such combinations. Chitosan may be processed into drug delivery systems using several techniques including spray-drying, coacervation, direct compression, and conventional granulation processes. The method used is ionic gelation method. The different ratio of drug and polymer were used. Chitosan was dissolved in acetic aqueous solution (1 mg/ml). 0.5 %w/v of Tween 80 was added to the chitosan solution as a suspending agent, to prevent particle aggregation while stirring at 25oC, 4 ml TPP aqueous solution with various concentrations (0.4, 0.6, 0.8, 1.0 mg/ml) was added into 15 ml chitosan/drug solution, respectively. The in-vivo mucoadhesion study was carried out by fluorescence probe method. The formulation with drug: polymer ratio 1:2 was the best formulation as seen by the various evaluation parameters. Drug interaction studies have also revealed that there is no interaction between drug and excipients.
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